Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

نویسندگان

  • Ignacio Melero
  • Ivan Martinez-Forero
  • Juan Dubrot
  • Natalia Suarez
  • Asis Palazón
  • Lieping Chen
چکیده

Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

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عنوان ژورنال:
  • Clinical cancer research : an official journal of the American Association for Cancer Research

دوره 15 5  شماره 

صفحات  -

تاریخ انتشار 2009